Etizolam is a benzodiazepine analog. It possesses amnesic, anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties.
Etizolam is a thienodiazepine which is chemically related to a class of substances known as benzodiazepines.
Benzodiazepines are a class of drugs that produce central nervous system (CNS) depression and are commonly used to treat insomnia and anxiety.
Etizolam displays significant improvement in anxiety and depressive symptoms.
Effective sedative helps in inducing sleep.
Provides significant symptomatic relief (including chronic anxiety, phobic ideas, associated depressive symptoms and episodic anxiety.
Short-term treatment of insomnia.
Short-term treatment of anxiety or panic attacks, if a benzodiazepine is required.
In depression
Etizolam is a CNS depressant with anxiolytic, anticonvulsant, sedative-hypnotic and muscle relaxant effects. It acts on the benzodiazepine site of the GABA-A receptor as an agonist to increase inhibitory GABAergic transmission throughout the central nervous system.
Absorption
Etizolam is well absorbed from the intestines with a biological bioavailability of 93% following oral administration. After a single oral dosing of 0.5mg Etizolam, it takes approximately 0.9 hours to reach the peak plasma concentration of 8.3 ng/mL.
Route of eliminationIn a rat study, the amounts of Etizolam excreted was 30% in urine was 70% in feces, while the values in a mouse study were 40% in urine and 60% in feces.
Half-lifeThe average elimination half-life of Etizolam following a single oral dose of 0.5mg is 3.4 hours.
Adverse EffectsIn general, Etizolam may cause similar adverse effects as the classical benzodiazepines that is sedation, sleepiness, muscle relaxation, ataxia, slurred speech, and loss of consciousness.
Anxiety disorders associated with depression:1 mg two to three times a day (maximum 3 mg per day)
For panic disorder: 0.5 mg two times per day (maximum 1 mg per day)
For insomnia 1 2 mg once daily before bedtime.
1 mg dose of Etizolam is approximately equivalent to a 10 mg dose of diazepam.
Possesses marked antidepressant effect better than alprazolam or bromazepam.
Clinical studies suggest that Etizolam is approximately 10 times as potent as diazepam in producing hypnotic effects.
Etizolam is metabolized by the liver and is contraindicated in those with severely impaired hepatic function.
Pregnancy, Lactation and neonates
It is a non-narcotic drug.
It is 10 times more potent than diazepam in producing hypnotic effects.
Has no abuse because of short-term acting
